全文获取类型
| 收费全文 | 35262篇 |
| 免费 | 2290篇 |
| 国内免费 | 1891篇 |
专业分类
| 耳鼻咽喉 | 471篇 |
| 儿科学 | 771篇 |
| 妇产科学 | 128篇 |
| 基础医学 | 2662篇 |
| 口腔科学 | 73篇 |
| 临床医学 | 4561篇 |
| 内科学 | 5127篇 |
| 皮肤病学 | 43篇 |
| 神经病学 | 5559篇 |
| 特种医学 | 2214篇 |
| 外国民族医学 | 1篇 |
| 外科学 | 9570篇 |
| 综合类 | 4766篇 |
| 现状与发展 | 5篇 |
| 预防医学 | 602篇 |
| 眼科学 | 111篇 |
| 药学 | 1435篇 |
| 17篇 | |
| 中国医学 | 516篇 |
| 肿瘤学 | 811篇 |
出版年
| 2024年 | 43篇 |
| 2023年 | 599篇 |
| 2022年 | 724篇 |
| 2021年 | 1354篇 |
| 2020年 | 1323篇 |
| 2019年 | 1351篇 |
| 2018年 | 1362篇 |
| 2017年 | 1186篇 |
| 2016年 | 1093篇 |
| 2015年 | 1213篇 |
| 2014年 | 2194篇 |
| 2013年 | 2381篇 |
| 2012年 | 1792篇 |
| 2011年 | 1966篇 |
| 2010年 | 1779篇 |
| 2009年 | 1640篇 |
| 2008年 | 1628篇 |
| 2007年 | 1724篇 |
| 2006年 | 1598篇 |
| 2005年 | 1373篇 |
| 2004年 | 1166篇 |
| 2003年 | 1096篇 |
| 2002年 | 950篇 |
| 2001年 | 770篇 |
| 2000年 | 669篇 |
| 1999年 | 572篇 |
| 1998年 | 533篇 |
| 1997年 | 448篇 |
| 1996年 | 352篇 |
| 1995年 | 405篇 |
| 1994年 | 370篇 |
| 1993年 | 325篇 |
| 1992年 | 318篇 |
| 1991年 | 257篇 |
| 1990年 | 247篇 |
| 1989年 | 260篇 |
| 1988年 | 191篇 |
| 1987年 | 165篇 |
| 1986年 | 207篇 |
| 1985年 | 335篇 |
| 1984年 | 291篇 |
| 1983年 | 195篇 |
| 1982年 | 216篇 |
| 1981年 | 197篇 |
| 1980年 | 180篇 |
| 1979年 | 80篇 |
| 1978年 | 89篇 |
| 1977年 | 60篇 |
| 1976年 | 58篇 |
| 1975年 | 45篇 |
排序方式： 共有10000条查询结果，搜索用时 437 毫秒
91.
92.
93.
94.
95.
96.
97.
98.
Biao Zhou Wei Li Guizhen Zhao Bing Yu Baihui Ma Zhujiang Liu Nan Xie Yi Fu Ze Gong Rongbo Dai Xiaoming Zhang Wei Kong 《Journal of vascular surgery》2019,69(3):921-932.e3
Objective
The purpose of this study was to investigate whether rapamycin inhibits the development of thoracic aortic aneurysm and dissection (TAAD) in mice.Methods
Three-week-old C57BL/6J male mice were fed a normal diet and randomized into a control group (n = 6), β-aminopropionitrile fumarate (BAPN) group (Gp A; n = 15), BAPN plus rapamycin (5 mg) group (Gp B; n = 8), and BAPN plus rapamycin (10 mg) group (Gp C; n = 8). Gp A, Gp B, and Gp C were administered BAPN (1 g/kg/d) for 4 weeks. One week after BAPN administration, Gp B and Gp C were treated with rapamycin (5 mg/kg/d or 10 mg/kg/d) through gavage for 21 days. Thoracic aortas were harvested for Western blot and immunofluorescence staining at day 14 and for morphologic and histologic analyses at day 28.Results
BAPN treatment induced TAAD formation in mice. The incidence of TAAD in control, Gp A, Gp B, and Gp C mice was 0%, 80%, 25%, and 37.5%, respectively. Smaller thoracic aortic diameters (ascending aorta and arch) were observed in Gp B and Gp C mice than in Gp A mice (Gp B vs Gp A: ascending aorta, ex vivo, 1.07 ± 0.21 mm vs 1.80 ± 0.67 mm [P < .05]; aortic arch, ex vivo, 1.51 ± 0.40 mm vs 2.70 ± 1.06 mm [P < .05]; Gp C vs Gp A: ascending aortas, ex vivo, 1.10 ± 0.33 mm vs 1.80 ± 0.67 mm [P < .05]; aortic arch, ex vivo, 1.55 ± 0.56 mm vs 2.70 ± 1.06 mm [P < .05]). TAAD mice exhibited elastin fragmentation, abundant inflammatory cell infiltration, and significantly increased matrix metalloproteinase production in the aorta, and rapamycin treatment alleviated these changes. The protein levels of p-S6K and p-S6 in TAAD aortic tissues increased significantly, whereas they were suppressed by rapamycin.Conclusions
Rapamycin suppressed TAAD formation, probably by inhibition of mechanistic target of rapamycin signaling and reduction of inflammatory cell infiltration and matrix metalloproteinase 9 production. Targeting of the mechanistic target of rapamycin signaling pathway using rapamycin may be a favorable modulation for the clinical treatment of TAAD. 相似文献99.
100.
Viviana Maestrini Lucia I. Birtolo Sara Cimino Paolo Severino Massimo Mancone Marco Francone Sanjay M. Banypersad Flavia Ventriglia Luigi Tritapepe Fabio Miraldi Francesco Fedele 《Echocardiography (Mount Kisco, N.Y.)》2019,36(5):992-995
A 20‐year‐old Congolese woman presented with presyncope, dyspnea, and anasarca. Past medical history was unremarkable. Echocardiography revealed a rare combination of giant right atrium (RA), a dilated and hypertrophied right ventricle, subvalvular pulmonary stenosis (subPS), severe tricuspid regurgitation (TR), pericardial effusion and what appeared to be a spontaneously closed ventricular septal defect (VSD). Cardiac Magnetic Resonance and Cardiac Computed Tomography confirmed the findings excluding the presence of intra‐cardiac and extra‐cardiac shunt and other associated congenital anomalies. The patient underwent subPS resection, right atrioplasty, and tricuspid annuloplasty. Multimodality approach facilitated the detection of the abnormalities and provided clarity when determining the optimal surgical strategy. 相似文献